Myostatin 1mg

Description

Myostatin 1mg

Myostatin is an endogenous, negative regulator of muscle growth determining both muscle fiber number and size. The myostatin pathway is conserved across diverse species ranging from zebrafish to humans. Experimental models of muscle growth and regeneration have implicated myostatin as an important mediator of catabolic pathways in muscle cells. Inhibition of this pathway has emerged as a promising therapy for muscle wasting.

Myostatin (MSTN) is a secreted member of the transforming growth factor-β (TGF-β) family. Also known as growth differentiation factor 8, MSTN signals through the activin receptors and functions as a negative regulator of skeletal muscle growth. MSTN is produced by skeletal muscle, circulates in the bloodstream, and acts to limit muscle mass. Overexpression of MSTN in mice produces a dramatic loss of skeletal muscle and body fat. Paradoxically, mice lacking MSTN exhibit increased muscle mass but, surprisingly, reduced adipose tissue mass. This observation was explained by increased fatty acid oxidation. Physical activity reduces MSTN production, and inhibition of MSTN has been related to the positive effects of physical activity on metabolism and skeletal muscle mass. Interestingly, skeletal muscle MSTN expression and plasma circulating concentrations are increased in obesity. A link between MSTN and proinflammatory cytokines has been previously suggested. MSTN expression is increased in C2C12 myotubes treated with TNF-α, while myotubes treated with MSTN increase the expression and secretion of IL-6. These relations provide new clues to the mechanisms potentially linking inflammation with the loss of muscle mass. Moreover, systemic levels of TNF-α and IL-6 are not increased after a high-fat diet in MSTN-deficient mice as compared to wild-type animals.

Formula:                   C133H227N43O33

Molar Mass:             2956.6 G/MOL

THIS PRODUCT IS INTENDED FOR RESEARCH ONLY. This designation allows the use of research peptides strictly for in vitro testing and laboratory experimentation only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product is NOT for human use and can be harmful if ingested. This product is for research/laboratory use only. This product is NOT in a sterile solution and is NOT to be injected. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and should not be misbranded, misused or mislabeled as a drug, food or cosmetic.