IGF-I(1-3) 1mg

Description

IGF-I(1-3) 1mg

IGF-1 (1-3) is a naturally occurring, endogenous protein, as well as drug, and truncated analogue of insulin-like growth factor 1 (IGF-1). (1-3)IGF-1 lacks the first three amino acids at the N-terminus of IGF-1 (for a total of 67 amino acids, relative to the 70 of IGF-1). As a result of this difference, it has considerably reduced binding to the insulin-like growth factor-binding proteins (IGFBPs) and enhanced potency (about 10-fold in vivo) relative to IGF-1.

Insulin-like growth factors (IGFs) are key growth-promoting peptides that act as both endocrine hormones and growth factors. Most IGF molecules are bound by one of the members of the IGF-binding protein (IGFBP) family. The IGF protein family consists of signaling proteins, cell membrane receptor proteins and IGF binding proteins.

Another peptide hormone that is similar to IGF-1 is called IGF-2. Both of these growth factors have a similar structure to insulin. They’re both produced primarily in the liver, as well as in other tissues, in response to the release of growth hormone by the pituitary gland. Both are considered extensions of human growth hormone because they have many of the same effects.

• As binding proteins, IGF-1 and IGF-2 both bind to and activate different receptors, causing the growth of different cells and tissues.
• When IGF-1 binds to receptors it primarily stimulates hypertrophy (increase in cell size) and hyperplasia (increase in cell number) in both children and adults. It does this in tissues, including muscles and bones.
• IGF-2 is highly active during fetal development, helping with cell growth (proliferation) and tissue formation, but becomes much less active after birth.

The amino acid sequence of (1-3)IGF-1 is TLCGAELVDA LQFVCGDRGF YFNKPTGYGS SSRRAPQTGI VDECCFRSCD LRRLEMYCAP LKPAKSA.

Formula:                    C319H501N91O96S7

Molar Mass:              7 371.48 g/mol -1

THIS PRODUCT IS INTENDED FOR RESEARCH ONLY. This designation allows the use of research peptides strictly for in vitro testing and laboratory experimentation only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product is NOT for human use and can be harmful if ingested. This product is for research/laboratory use only. This product is NOT in a sterile solution and is NOT to be injected. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and should not be misbranded, misused or mislabeled as a drug, food or cosmetic.