IGF 2 1200iu
Firstly, the major role of IGF 2 is as a growth promoting hormone during gestation. In addition, the IGF 2 gene provides instructions for making a protein called insulin-like growth factor 2. This protein plays an essential role in growth and development before birth.
How IGF 2 works:
IGF 2 exerts its effects by binding to the IGF 1 receptor and to the short isoform of the insulin receptor (IR-A or exon 11-). It may also bind to the IGF 2 receptor (also called the cation-independent mannose 6-phosphate receptor), which acts as a signaling antagonist; that is, to prevent IGF 2 responses.
In the process of folliculogenesis, IGF 2 is created by thecal cells to act in an autocrine manner on the theca cells themselves, and in a paracrine manner on granulosa cells in the ovary. IGF 2 promotes granulosa cell proliferation during the follicular phase of the menstrual cycle, acting alongside follicle stimulating hormone (FSH).
After ovulation has occurred, IGF 2 promotes progesterone secretion during the luteal phase of the menstrual cycle, together with luteinizing hormone (LH). Thus, IGF 2 acts as a co-hormone together with both FSH and LH.
- promotes the growth and division (proliferation) of cells in many different tissues.
- The IGF 2 locus is one of the imprinted gene clusters in human chromosome 11p15. 5 and plays a primary role in muscle cell development
Molecular Formula: C26H45N7O11
Molecular Mass: 631.7 g/mol
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