GnRH (Gonadorelin) 5mg

Description

GnRH (Gonadorelin)

Gonadotropin-releasing hormone (GnRH) is a decapeptide produced in the hypothalamus. It is also known as luteinizing hormone-releasing hormone (LHRH), gonadoliberin, luliberin, gonadorelin, and GnRH I. Despite various functions reported for GnRH in mammals, biochemical, molecular, neuroanatomical, pharmacological, and physiological studies have mainly focused on its role as a gonadotropin-releasing factor. In human, the reproductive system is regulated by a process that requires the action of hormones in the hypothalamic–pituitary–gonadal (HPG) axis loop. In adult males and females, the hypothalamic pulsatile secretion of the GnRH results in the expression and release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary gland. FSH and LH (gonadotropins) regulate the function of the testes and ovaries (gonads). In both sexes, FSH stimulates gamete production, and LH stimulates the expression of steroid hormones by the gonads. An increased level of steroid hormones inhibits GnRH production through a negative feedback loop. GnRH (GnRH-1 in particular) is a decapeptide, with the amino acid structure (pyro)Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂.

The amino acid structure of GnRH is identical in essentially all mammalian species; with the exception of the central Tyr-Gly-Leu-Arg segment, the amino acids of GnRH are highly conserved among vertebrate species. The GnRH-1 gene (GNRH1) is located on human chromosome 8 and produces a 92–amino acid precursor peptide called prepro-GnRH, which includes a signal sequence (23 amino acids), GnRH (10 amino acids), a proteolytic processing site (3 amino acids), and GnRH-associated peptide (56 amino acids) The latter peptide can stimulate gonadotropin secretion and inhibit prolactin secretion, although its precise physiologic role, if any, remains unclear. The actions of GnRH are mediated through the GnRH type I receptor.

Formula:                    C55H75N17O13

Molar Mass:              1 182.311 G/MOL -1

THIS PRODUCT IS INTENDED FOR RESEARCH ONLY. This designation allows the use of research peptides strictly for in vitro testing and laboratory experimentation only. Bodily introduction of any kind into humans or animals is strictly forbidden by law. This product is NOT for human use and can be harmful if ingested. This product is for research/laboratory use only. This product is NOT in a sterile solution and is NOT to be injected. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and should not be misbranded, misused or mislabeled as a drug, food or cosmetic.